Stephen L. Hoffman M.D

Stephen L. Hoffman M.D., D.T.M.H., D.Sc. (hon), FASTMH, CAPT, MC, USN (RET)
Chief Executive and Scientific Officer:

Dr. Hoffman has over 25 years of experience building and managing large, successful research and development programs. From 1987-2001 he was Director of the Malaria Program at the Naval Medical Research Center where he built a focused professional team of over 100 individuals in the United States and overseas working on all aspects of malaria research, but especially vaccine development and genomics. Dr. Hoffman and his team were leaders in the effort to sequence the P. falciparum genome and conducted the first studies in the world that showed that DNA vaccines elicited killer T cell responses in humans. In early 2001 Dr. Hoffman retired from the Navy and joined Celera Genomics as Senior Vice President of Biologics to create a program to utilize genomics and proteomics to produce new biopharmaceuticals. He established this program, organized the effort that successfully sequenced the genome of the mosquito responsible for most transmission of malaria in Africa, Anopheles gambiae, and left Celera in August 2002 to found Sanaria. He holds several professorships, and chairs or serves on multiple advisory boards. He is a past president of the American Society of Tropical Medicine and Hygiene, has edited two books on malaria vaccine development, been the author of more than 380 scientific publications, and has numerous patents. He is the most highly cited author in the world for scientific papers on malaria published between 1995 and 2005. He received his B.A. from the University of Pennsylvania, M.D. from Cornell University Medical College, Diploma in Tropical Medicine and Hygiene from the London School of Hygiene and Tropical Medicine, and did residency training at the University of California, San Diego. He is board certified in Family Practice. In 2004 he was elected to membership in the Institute of Medicine of the National Academies.

Kim Lee Sim

B. Kim Lee Sim, PhD
Executive Vice President Process Development and Manufacturing:

Dr. Sim, has been associated with Sanaria since its inception, and is a member of the board of Sanaria. She is also President and Chief Scientific Officer of Protein Potential LLC (, a vaccine development company, which she founded in 2003. Dr. Sim did her undergraduate (B.Sc., Honors, First Class) and graduate studies (M.Sc., Ph.D.) at the University of Malaya, Kuala Lumpur, Malaysia. After a post doctoral fellowship in molecular biology at Harvard School of Public Health, she was a research scientist at the Walter Reed Army Institute of Research and an adjunct faculty at the Uniformed Services University of Health Sciences, a research assistant professor at Johns Hopkins School of Public Health, and an Expert at the National Institute of Allergy and Infectious Diseases, NIH. In 1993 Dr. Sim left the NIH to join a start up company, EntreMed Inc, as Research Director of Molecular Biology, and in 1999 she was appointed Vice President Pre-Clinical Research and Development. At EntreMed, Dr. Sim established and managed the development program for anti-angiogenic proteins for the therapy of cancer, and developed the process that led to the cGMP manufacture of tens of kilograms of recombinant Angiostatin and Endostatin, two anti-angiogenic proteins that entered Phase II clinical trials. Dr. Sim has published more than 85 scientific papers, and has 7 issued and more than 15 pending patents.


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